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Li B, Zhang X, Zhang Q, Zheng T, Li Q, Yang S, et al

But they are changing the landscape of medicine because they hit a fundamental biology we have ignored for too long: the gut-brain-metabolic axis

P.HuddlestonC

Phase 2b primary endpoints failed in the largest published trial

Although urocortin 1 can also activate CRH-R1, urocortin 1 knockout mice appear to have normal HPA axis function, suggesting that urocortin 1 does not have a significant regulatory role on the axis (61)