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Dissociative anesthetics, including ketamine and nitrous oxide, impair glutamatergic transmission and mitochondrial function, thereby exacerbating excitotoxicity and neuronal apoptosis

Chapter 9

Additionally, Cr exerts anti-inflammatory effects by inhibiting pro-inflammatory cytokines such as TNF- and interleukin 6 (IL-6) which are often elevated under HS conditions (228)