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In accordance with such a variety of functions, isoforms of this heterogeneous protein family are found in many prokaryotes as well as in the cytosol, nucleus, mitochondria, chloroplasts and/or secretory pathway of eukaryotes 1,2,3,4,5,6,7,8

The primary factors driving the growth of the nutraceutical and functional food markets are the increasing prevalence of obesity, diabetes, eye health problems, cardiovascular diseases, changing food consumption patterns in developing markets, growing interest in preventive medicine, and growing demand for multivitamins

As a consequence, the unrestrained and potentially lethal accumulation of ROS threatens to damage many biomolecules: lipids, proteins, DNA, and host cells

W., Kugler, L

Widening the therapeutic window for redox-targeting drugs Given that SCLC cells are unable to adapt to redox-targeting drugs, such as TXNRD1 inhibitors, we hypothesized that activating the NRF2 pathway would enhance antioxidant defenses specifically in non-cancerous cells, thereby further widening the therapeutic window