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Secondly, synthetic polymers like PLGA benefit from FDA and EMA approvals, degrading into lactic and glycolic acids that feed into normal metabolic pathways, underpinning clinically established formulations (e.g., Lupron Depot) with negligible long-term toxicity (Frigaard et al., 2022)

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Compounded semaglutide is not FDA-approved and may vary in quality and purity

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