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Accumulating evidence shows that the inter-organelle connection between mitochondria and endoplasmic reticulum (ER), known as the mitochondria-associated ER membrane (MAM), plays a crucial role in PD pathogenesis [5, 6]

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2.7.1.2 Trends in consumption during the 1960s and 1970s Figure 2.7.2 shows a marked decline in per capita consumption in the early and mid-1960s, which was the time during which landmark reports about the health effects of smoking were released in Britain in 1962 1 and in the US in 1964 2 and 1967