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It has been found that vitamin D increases the number of Tregs, in turn decreasing the chance of autoimmune diseases occurrence such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS), Hashimoto Thyroiditis (HT), and multiple sclerosis (MS) [109]

For instance, bile acids derived from the gut microbiota can increase the proportion of regulatory T cells in the colon of mice, thereby reducing their susceptibility to colitis [9]

Olive JK, Zhou N, Mitchell KG, Corsini EM, Hofstetter WL, Mehran RJ, Rice DC, Sepesi B, Swisher SG, Vaporciyan AA, Walsh GL, Antonoff MB

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Antidepressant-like effects of Ashwagandha ( Withania Somnifera ) on chronic unpredictable mild stress-induced depression in adolescent rats