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Am J Med Genet 101:911 Louis-Bar M (1941) Sur un syndrome progressif comprenant des tlangiectasies capillaires cutanes et conjonctivales symtriques, disposition naevode et des troubles crbelleux

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Impaired mitochondrial function due to the downregulation of nuclear-encoded genes involved in oxidative phosphorylation increases ROS production, which in turn phosphorylates the serine residues of insulin receptors and IRSs, thereby resulting in SLCI and a reduction in IR

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this effect was less evident for Thrb , which already had a lower expression