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Excess accumulated body fat causes mitochondrial dysfunction, inflammation, hyperlipidemia, and insulin resistance, leading to various metabolic health problems (Zhang et al., 2022) and adipokine production ( 3 PQQ reduces body fat accumulation to prevent obesity Obesity can be evaluated based on body fat content because elevated visceral and hepatic fat levels increase the risk of developing chronic diseases (Table 1

True allergic reactions involve hives spreading beyond the injection site, throat swelling, or breathing difficulty

Future research will need to address these challenges, optimize delivery methods, and validate findings in more complex systems to advance gene therapy for epilepsy

Acetaminophen toxicity: The most well-established clinical application of glutathione repletion is the treatment of acetaminophen (paracetamol) overdose