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In addition, triamterene is a weak folic acid antagonist and can contribute to the development of megaloblastic anemia in patients with depleted stores of folic acid such as occur in hepatic cirrhosis

the inventors also surprisingly found inhibitory activity with certain embodiments of the invention where R 1 is methyl with dual positional substitutions (see e.g., compounds 2j, 2m, 2k, and 2l, Table 2)

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