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This underdiagnosis can lead, besides death in 20% when it is not appropriately treated, to Korsakoffs syndrome, a severe dysfunction often following untreated Wernickes encephalopathy, that does not remit even with thiamine treatment and is associated with chronic alcohol abuse and chronic thiamine deficiency (40, 42)

This can lead to: loss of strength and all-over muscle weakness, double vision, blurred vision, drooping eyelids, hoarseness or change or loss of voice, trouble saying words clearly, loss of bladder control, trouble breathing, and trouble swallowing

Prescribed preparations where application, tolerability, route, and practical use instructions are important

Forced Activation : Contracts muscles at intensities/volumes the patient cannot achieve alone

Cells were treated with 40100 M KL1 or 110 M BIX-01294 in the presence of 50 g ml 1 Gen in 5 replicates for 48 h