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130 Angiogenesis is a critical process involving the formation of new blood vessels that supply cancer cells with essential oxygen and nutrients, establishing the material foundation for tumor growth and creating pathways for tumor cell invasion and metastasis

In fact, if it is not then there is a problem

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During ischemia, a large increase in the antioxidant defense system, such as glutathione augmentation, has been seen in an attempt to deal with oxidative stress [156,157]