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One possible way that may enable simultaneous induction of autophagosome biogenesis along with improved lysosomal function would be by increasing TFEB and/or TFE3 activities 271

61 Subsequently, two downstream signals are modulated by AKT: one is the inhibition of forkhead box O transcription factor (FOXO) through AKT-mediated direct phosphorylation, 62 and the other is the indirect activation of mammalian target of rapamycin complex 1 (mTORC1) via AKT-mediated phosphorylation and inactivation of tuberous sclerosis complex 2 (TSC2) and subsequent disrupted interaction of TSC1 and TSC2 63 (Fig

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The results showed that compared all other hydrogels treated, hydrogel treated with NIR irradiation showed more contraction of wound indicating better healing efficacy, (Fig

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