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Proapoptotic multidomain Bcl-2/Bax-family proteins: mechanisms, physiological roles, and therapeutic opportunities

To test whether low oxygen tension experienced by retinal cells can stimulate mitophagy, we injected Naive mice or those exposed to OHT (OHT) with pimonidazole, a compound that creates covalent adducts in cells that experience a partial pressure of oxygen lower than 10 mmHg (hypoxia)

Sur and Panda, 2017)

The initiation of the process is catalyzed by the intracellular iron pool, which reacts with hydrogen peroxide and superoxide to produce oxygen-centered radicals