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Aminoacids (like serine) are major one-carbon sources, and cancer cells are particularly susceptible to the deprivation of one-carbon units by serine restriction or inhibition of de novo serine synthesis

However, the high total-body content of glutathione (probably in the range of 40 to 80 gm in a 70 kg adult) and the relatively short half-life of this reactive and metabolically important compound (4 to 10 hours in most tissues) render glutathione replacement extremely difficult to achieve in practice

A multiinstitutional survey of the Wiskott-Aldrich syndrome

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