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Georgieva I, Aquino AJA, Plasser F, Trendafilova N, Khn A (2015) Intramolecular Charge-Transfer Excited-State Processes in 4-(N, N-Dimethylamino)benzonitrile: The Role of Twisting and the * State

lysosomes remained intact, demonstrating selectivity of organelle targeting In vivo tumour eradication pre-clinical studies have reported tumour eradication in nude mouse xenograft models following PNC-27 treatment Ovarian cancer models intraperitoneal mouse toxicity and maximum tolerated dose studies conducted alongside ex-vivo testing against primary patient-derived epithelial ovarian cancer cultures, demonstrating dose-dependent cytotoxicity including activity against chemotherapy-resistant ovarian cancer lines Haematological malignancy models near-complete cancer cell death reported in leukaemia models, including p53-deficient cells, via HDM-2 membrane binding Cervical cancer models confirmed selective killing of cervical cancer cells with no effect on untransformed cervical cells

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