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Nat Rev Nephrol (2018) 14:2647

Willcox et al., 2008)]

Environmental Health Perspectives 2003

More recently, studies of transgenic mouse models have revealed that the triplication of CBS gene also contributes to cognitive phenotypes and that CBS and DYRK1A show epistatic interactions ( CBS encodes a pyridoxal 5-phosphate-dependent enzyme that catalyzes the first reaction in the transsulfuration pathway

Mechanistically, mitochondrial dysfunction, as discussed above, is an increasingly recognized contributor, particularly in diabetic nephropathy, in which mitochondrial ROS production exceeds the local antioxidant capacity [13,34]