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Melanocortin-4 Receptor Agonists The melanocortin system has a highly significant role in the hypothalamic regulation of body weight and energy expenditure

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It requires a prescription and as a controlled substance, supply is strictly monitored, and distribution is limited

These medications are FDA-approved for chronic weight management in adults with a BMI 30 kg/m or 27 kg/m with at least one weight-related comorbidity, regardless of bariatric surgery history

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