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Nature 615 , 158167 (2023)

researchers building on or replicating that work need the same tool Cardiac and cytoprotective studies: Ischemia-reperfusion injury models have accumulated preclinical evidence for GHRP-6-mediated cardioprotection potentially through GHSR-1a pathways in cardiomyocytes and inflammatory modulation CNS/reward circuitry: GHSR-1a forms heterodimers with dopamine D1 receptors

Unlike vitamins or hormones, peptides bind to specific receptors on cells and trigger targeted processes (like collagen production or growth hormone release)

Growth hormone improved cardiac output, particularly during exercise (from 7.4+/-0.7 to 9.7+/-0.9 liters per minute, P=0.003), and enhanced ventricular work, despite reductions in myocardial oxygen consumption (from 56+/-6 to 39+/-5 ml per minute, P=0.005) and energy production (from 1014+/-100 to 701+/-80 J per minute, P=0.002)