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Type 2 diabetes is characterized by alterations in mitochondrial dynamics, OXPHOS, mitophagy, and calcium homeostasis, all of which contribute to the diseases complexity [147,148,149]

Reduced inflammation and dryness are frequently reported benefits

In a previous study, all COVID-19 patients (33 out of 33) were found to be Zn deficient, with a mean serum level of 6.9 1.1 moL/L, which is well below the Zn deficiency cutoff value of 10.7 moL/L (120)

Methods: Sandwich ELISAs to measure the matricellular fibrosis markers thrombospondin-2 (TSP2) and thrombospondin-4 (TSP4) as well as the metabolism/inflammation/fibrosis related markers insulin-like growth factor binding protein-7 (IGFBP7), CD163 and a disintegrin and metalloprotease thrombospondin like-9 (ADAMTS9) were developed in-house using combinations of recombinantly expressed proteins as well as commercial and self-produced monoclonal and polyclonal antibodies

10.58347/tml.2024.1694a 87 VallelianF.BuehlerP