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In addition to arbutin and glutathione, which have been widely used, The use of Chinese medicinal extracts integrates traditional Chinese medicine principles with modern cosmetic techniques to treat skin pigmentation using natural extracts from both animals and plants 36,37

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Moreover, in-sufficient empirical evidence, protection issues, disparities in potency, limited solubility, expensive and absence of regulations, herbal products with a short shell lifespan may contain toxins such as heavy metals (mercury, lead, etc.), herbicides as well as pathogens (Kalachaveedu et al., 2023

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Nakano, M., Yamamoto, T., Okamura, H., Tsuda, A., Kowatari, Y