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Samples were prepared in triplicate and were stored in the dark at 42 C with 25% relative humidity (RH) in an accelerated degradation chamber, as 2 weeks storage under these conditions is equivalent to approximately 6 weeks storage under ambient conditions [29, 30]

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Furthermore, the expansion of pathobionts like Peptostreptococcus can generate detrimental metabolites (e.g., indole derivatives), which directly upregulate cartilage-degrading MMP-13 (2628)

H., Liu, H