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doi: 10.3332/ecancer.2024.1783 68 KrgerH.BauerG

The peptide consists of 83 amino acids with a molecular weight of approximately 9.1 kDa, distinguished from native IGF-1 (70 amino acids) by two critical structural modifications: substitution of arginine for glutamic acid at position 3 and addition of a 13-amino acid extension at the N-terminus

The autophagy-inhibitor bafilomycin A1 (100 nM) and the autophagy-inducer rapamycin (10 M) were used as negative and positive controls, respectively

"The rationale for this segregation relates to the known capacity for varicella to establish latency in cranial nerve ganglia, especially cranial nerve V, and spread retrograde via sensory nerve fibers to the cerebral circulation," the researchers explained