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Graphical Abstract Similar content being viewed by others Background Ferroptosis, a regulated type of cell death resulting from iron-dependent lipid peroxidation, has been recognized as a crucial mechanism associated with the development of various diseases, including neurodegenerative, cardiovascular, digestive, musculoskeletal, and cancer-related diseases [1]

Although this happens quickly, foreign particles tend to leach the electrons from surrounding molecules, substantially damaging the nearby tissue before being asked to leave the body

Glutathione biosynthesis occurs in several, but not in all eukaryotic cell types through a well-coordinated and feedback-modulated process that needs one essential amino acid, cysteine, and two others, glutamic acid and glycine, that most cells can synthesize themselves from the intermediates of core metabolism

Cell Signall 2006

BMJ 371 , m4714 (2020)