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OCT4/SOX2 can bind to the promoter region of integrin 6 (also known as CD49f or ITGA6) and enhance its expression, and integrin 6 promotes multipotency and stemness in MSCs through the PI3K/AKT/p53 pathway (Yu et al., 2012)

Apart from playing important roles in stress signaling, ROS like H 2 O 2 are also involved in plants' growth and developmental processes like differentiation of cellulose rich cell wall, mediation of aleuronic cell death and stimulation of somatic embryogenesis (Neill et al., 2002

Nature 591, 131136

Similar results were found when investigating zebrafish, whereby simple wound healing required only early accumulation of ROS for JNK pathway activation, whilst injuries which necessitated new tissue formation required sustained H 2 O 2 production, activating apoptosis pathways as well as JNK 19,130