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A key cellular antioxidant, glutathione (GSH), is intimately involved in these processes by maintaining redox homeostasis and modulating signaling pathway activities [47]

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Phosphorylation, ubiquitination, and acetylation are common forms of PTMs that interact and collectively regulate protein function and metabolism within the cell

10.1146/annurev.pharmtox.44.101802.121851 77 KlimaczewskiC

For instance, NRF2 inhibitors, such as Brusatol and Brucein D, promote ubiquitination and proteasomal degradation of NRF2, enhancing chemosensitivity in cancers like AML, endometrial cancer, and pancreatic ductal adenocarcinoma