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2023 [cited 2024 Sep 28];15:205

Conclusions UroA might be a potential therapeutic agent to halt MM disease progression or to overcome resistance when used in combination

Protger les cellules des dommages

From the analysis of crystal and cryo-electron microscopy (cryoEM) structural studies it was possible to confirm the role of IMiDs as MGDs, since their binding to cereblon generates a neomorphic surface that confers greater selectivity for a given neo-substrate, resulting from the establishment of IMiD-dependent interactions 51,207