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By delivering NAD+ directly into the body, these injections aim to increase NAD+ levels beyond what might be achieved with oral supplements or diet

At week 32, that number approached 20%

Research interest nonetheless expanded considerably through the 1980s and 1990s, as investigators began exploring DSIP's broader neuroendocrine roles, including its interactions with the HPA axis, circadian timing systems, and stress-response pathways, establishing the compound as a multifunctional regulatory neuropeptide whose biological significance extends well beyond its original sleep-focused characterization

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