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This "paradoxical response" (where treatment temporarily makes symptoms worse) includes: Numbness and tingling Shooting pains Joint pain Increased sensitivity Temporary inflammation (swelling and irritation) While these symptoms generally indicate that treatment is working (as nerves begin to repair themselves), they can be distressing for patients and may require additional treatment for comfort

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Moreover, it also reduces the protein levels of PI3K, Akt, mTOR, and Ras, Raf, and p-ERK, indicating that H 2 S may regulate human TNBC cells through dual targeting of the PI3K/Akt/mTOR and Ras/Raf/ERK signaling pathways 369 (Fig