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Mechanistically, TXNIP may inhibit both Trx1 and Trx2, disrupting redox homeostasis and promoting ferroptosis

Lactate shuttling links histone Kla, particularly H4K12la, to neural stem cells (NSCs) proliferation through murine double minute 2 (MDM2)-p53 signaling pathway and eventually regulates cell cycle and endows NSCs neurogenic potential in the adult hippocampus

Analysis of pVHL/HIF-1 interactions defined short sequences of conserved residues within the internal transactivation domains of HIF-1 molecules sufficient for recognition by pVHL

Dual targeting of glutaminase 1 and thymidylate synthase elicits death synergistically in NSCLC

We examined here the plausibility of the simplest hypothesis that the change of lipid composition and its resulting membrane properties are themselves sufficient to cause cell death (Fig