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In the past, many cultures have used the bark, needles, resin, and nuts of pine trees as medicine ( In the 1940s, scientist Jacques Masquelier began studying the health effects of pine bark after learning that indigenous peoples of North America were using pine bark tea to heal scurvy and wounds ( Since then, pine bark extract has continued to increase in popularity as an herbal supplement

Known adverse reactions: Hypersensitivity/allergy can occur

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Excess Th1 compared with Th2 for prolonged periods of time, in the absence of acute infection, is known as Th1 dominance and is associated with tissue specific autoimmune diseases such as Hashimotos

Mol Cancer Res (2019) 17(5):116679