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1.2 A multiparametric approach in structural biology The ultimate goal of structural biology is to obtain information on the structure of a biological macromolecule with the highest possible resolution

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(2) the ability of the TJ to selectively allow paracellular transport of certain ion species acting as ion channel and (3) the ability of the TJs to maintain cell polarity, by blocking the free diffusion of proteins and lipids between the apical and basolateral domains of the plasma membrane