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The combined effects of proliferation-dependent epithelial damage and ROS-driven stress responses likely contribute to a cascade of events involving inflammatory signaling, extracellular matrix remodeling, and microbiome dysbiosis, collectively driving the progression from localized injury to systemic gastrointestinal toxicity

pmid:5923703 29

Akkermansia muciniphila-derived acetate activates the hepatic ampk/sirt1/pgc-1 Axis to alleviate ferroptosis in metabolic-associated fatty liver disease

Stress & hydration: Manage stress and stay well hydrated, especially if GI side effects reduce intake

Carbohyd Polym 92:905920