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Pattern across both trials Nausea, vomiting, and diarrhea peaked during dose escalation and tapered during maintenance

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While individual sensitivity varies, caffeine has a half-life of approximately 5 to 6 hours, meaning half of the caffeine from an afternoon coffee remains in your system at bedtime

PLoS ONE 10(4):e0123454 Drmic D, Samara M, Vidovic T, Malekinusic D, Antunovic M, Vrdoljak B et al (2018) Counteraction of perforated cecum lesions in rats: Effects of pentadecapeptide BPC 157, L-NAME and L-arginine