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Further research has demonstrated that 4-HNE binds to A polypeptides to form covalent complexes, promoting covalent cross-linking of A polypeptides and protofibril formation (Siegel et al., 2007)

doi: 10.3389/fnins.2026.1810486 Received 13 February 2026 Revised 05 April 2026 Accepted 24 April 2026 Published 14 May 2026 Volume 20 - 2026 Edited by Glaura Scantamburlo Alves Fernandes, State University of Londrina, Brazil Reviewed by Sabyasachi Dash, AstraZeneca, United States Alireza Khoshrou, Mashhad University of Medical Sciences, Iran Updates Copyright 2026 Roamcharern and Yubolphan

Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2

The different effects observed between ambient heat stress and in vitro heat stress may be caused by the differences in the responses of both models to high temperatures

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