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Abbreviations ARHL: Age-related hearing loss AC: Air conduction BC: Bone conduction WHO: World Health Organization TCM: Traditional Chinese medicine HCs: Hair cells OHCs: Outer hair cells IHCs: Inner hair cells SV: Stria vascularis EP: Endocochlear potential SL: Spiral ligament SGNs: Spiral ganglion neurons GWAS: Genome-wide association study ROS: Reactive oxygen species SOD2: Superoxide dismutase 2 TNF: Tumor necrosis factor IL-1: Interleukin 1 CAT: Catalase GPx: Glutathione peroxidase GR: Glutathione reductase GSH: Glutathione NAC: N-acetylcysteine NIHL: Noise-induced hearing loss Cyt-c: Cytochrome c JNK: C-Jun N-terminal kinase NGF: Nerve growth factor IGF-1: Insulin-like growth factor 1 THSG: 2,3,4,5-Tetrahydroxystilbene-2-O--D-glucoside HSP: Heat shock protein HO-1: Heme oxygenase-1 ABR: Auditory brainstem response SAMC: S-Allylmercaptocysteine DD: Diallyl disulfide SAC: S-Allylcysteine GB: Ginkgolide B References Chadha S, Kamenov K, Cieza A

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GPX4, a crucial oxidoreductase, is essential for removing lipid peroxidation products by using GSH as a reducing agent [107]

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