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38 Iron overload Although iron is a helpful component of the human body and the major micronutrient in the human diet, involved in crucial cellular functions and metabolic processes, excessive iron increases the production of ROS, leading to cell dysfunction or death, tissue damage, and organ disease

While H 2 O 2 did not directly contribute to polyamine-induced cell death under our experimental conditions, polyamines have previously been shown to enhance cellular sensitivity to RSL3-induced ferroptosis through H 2 O 2 generation 46

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Anti-Inflammatory & Cognitive Support Chronic inflammation is a hallmark of aging, and GHK-Cu helps restore balance by: Downregulating NF-kB and inflammatory cytokines like TNF-alpha, IL-6, and IL-1

In a normal or resting state, Nrf2 molecules are tightly bound in the cytoplasm by Keap-1, rendering them inactive