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Because of Grx2s high affinity to oxidized targets, CoA mixed disulfide and glutathione disulfide were easily reduced due to TRs ability to reduce both disulfide bridges and mixed glutathione disulfide at Grx2s catalytic Cys sites [22, 52, 53]

In brief, patient-related data including RA disease debut and duration, modified health assessment questionnaire (MHAQ) 44 , RA disease activity score (DAS28-ESR) 45,46 , joint damage, and patient global health assessment scored on a visual analogue scale (VAS) 47 were obtained