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FerryDRSmithAMalkhandiJFyfeDWdeTakatsPGAndersonDet al

Although saikosaponins have poor intestinal absorption due to their large molecular mass, high molecular flexibility, and high hydrogen-bonding capacityfeatures that limit membrane permeabilitycertain subtypes (saikosaponin a, b1, d, g, c) have been shown to exhibit relatively high bloodbrain barrier permeability in a microdialysis experiment, making them potential antidepressants (Yu et al., 2012

Endocrinology 135 , 10661072 (1994)

Cheng Z, Al Zaki A, Hui JZ, Muzykantov VR, Tsourkas A (2012) Multifunctional nanoparticles: cost versus benefit of adding targeting and imaging capabilities