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Senolytics Improve Physical Function and Extend Healthspan in Aged Mice

BP has many pharmacological properties and can be used to treat metabolic abnormalities such as hyper-dyslipidemia, obesity, diabetes, and cardiovascular diseases (20, 21)

Recording of electroretinograms (ERGs) in mice and rats Scotopic and photopic ERGs were recorded using an Espion ERG machine (Diagnosys LLC, Littleton, MA) as previously described [9]

GOLD fitness function is made up of four components: Protein-ligand hydrogen bond energy, Protein-ligand van der Waals energy, ligand internal van der Waals energy and ligand torsional strain energy

Because KPV is a small, naturally occurring tripeptide fragment, it is generally well tolerated