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Furthermore, by inhibiting caspase-1, IL-1 expression and matrix metalloproteinase-9 (MMP-9) activity are reduced, subsequently reducing BBB damage, improving nerve function, and attenuating brain edema

The PEP-pyruvate-oxaloacetate node: variation at the heart of metabolism

Metabolic flux isas elaborated especially by Westerhoff and colleagues (e.g., van Eunen et al., 2011)subject to hierarchical regulation involving changes in enzyme levels, and to metabolic regulation including modulations of the activity of pre-existing enzymes

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doi: 10.1016/j.joim.2018.11.004