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But because they don't break down and might not be biocompatible, they can't be used for lengthy periods of time

median (range) tumor size was 2.7 (1.29.3)/2.7 (1.47.0) cm

Increased inflammation, a root of nearly all chronic disease, including heart disease

Deshmukh R

Local corticosteroids, calcineurin inhibitors and phototherapy are still the basis of treatment, and long-term use of steroids can lead to decreased immunity (Whitton et al., 2016)