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Also supports proliferation through growth factor pathway modulation

Deficiency can occur when serum vitamin B12 levels remain inadequate long term

Experimental modulation of endothelial survival, angiogenic signaling and metabolic state reveals that intact tyrosine kinase receptor (Tie2) signaling, glycolytic competence of peritubular capillary endothelial cells, and sustained VEGF-A-vascular endothelial growth factor receptor 2 (VEGFR2) communication from injured TECs are all required to maintain endothelial identity, prevent EndMT and limit microvascular rarefaction [121]

Ewels, P., Magnusson, M., Lundin, S

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