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However, a supraphysiological concentration of H 2 O 2 (above 100 nM) can irreversibly modify and cause permanent impairment of DNA, proteins, or biomolecules [36, 37], eventually leading to cell growth arrest or even senescence and death, a condition known as OS (Fig

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Mario Valentino, University of Malta, Malta Updates Copyright 2020 Belov Kirdajova, Kriska, Tureckova and Anderova

It is also a cofactor for cortisol, epinephrine, norepinephrine, and dopamine.* One of the effects of adrenal fatigue is immune response