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Classically activated (M1-type) and alternatively activated (M2-type) macrophages are often considered two distinct activation states of macrophages, although this division is oversimplified [355]

The experimental mouse models of autoimmune encephalomyelitis (EAE) and cuprizone (a copper-chelator causing demyelination) are the most commonly employed animal models used to study different aspects of MS pathology

Candidate compounds or drugs that could significantly reverse the disease-related signatures of gene expression were further validated in vitro , showing that this computational method is a viable approach for identifying novel therapeutics