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The emerging challenge was to modify the naturally available compounds for multiple uses without compromising their vitality

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As we have documented the tolerability of L-PAM+BSO when supported by autologous stem cell infusion in heavily pretreated relapsed and/or refractory neuroblastoma patients (NANT phase I study, NCT00005835, www.clinicaltrials.gov), using myeloablative L-PAM+BSO is clinically feasible

Patients with PCOS have lower levels of serum LC [19], which may be related to insulin resistance and hyperandrogenism in affected patients