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[21] Adjunctive agents, such as beta-blockers for rapid heart rate (tachycardia), anticonvulsants for neural excitability, and trazodone for insomnia, may help reduce the risk of severe withdrawal complications

Surgical procedures of the CCI model The chronic constriction injury (CCI) model of the sciatic nerve was established to induce sciatic NP in mice, following a previously described protocol with minor modifications 27

ROS are produced by the electrons that leak from respiratory chain complexes (65, 66)

Arch Immunol Ther Exp (Warsz) 2023, 71 (1), 16

In one embodiment, the non-human animal includes at least a part of a human immunoglobulin gene