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1) Weight management endpoints in once weekly clinical trial designs The core published cagrilintide dataset is the multicentre randomised phase 2 trial (Lau et al., The Lancet 2021)

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In light of the observed background of these metabolites in rats, which may also occur in humans, and the fact that our calculations were based on relative excretion rates of the completely N -acetylated metabolites in rats, we consider that analysis of NAcCys-BDA-Lys and NAcCys-BDA-Lys in human urine is unlikely to provide accurate estimates of human exposure to furan