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[Google Scholar] 30.Liu S, Chen G, Prasad PN and Swihart MT, Chem

AGEs cross-linking with proteins Once AGEs are formed, they can cause multiple detrimental effects, leading to alteration of cardiovascular structure and inflammation of blood vessels, ultimately affecting the health of the cardiovascular system [32]

Iron metabolism heavily relies on the interactions of iron response elements (IREs) and iron regulatory proteins (IRPs), collectively known as IRE-IRPs, to maintain cellular homeostasis

PMID: 70 XiongHWeiBHuangYMaJZhangYWangQet al

For example, it has been shown that exceeding the upper limit of selenium intake (400 g/d) can lead to selenotoxicity, but no significant symptoms of toxicity were observed when selenium was ingested in the form of SeNPs (1,600 g/d), and some selenotoxicity symptoms did not occur until even an intake of 3,200 g/d (255)