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Improved EL-4 agonists and antagonists can be generated by the reassembly (optionally in combination with other directed evolution methods described herein) of EL-4 or soluble EL-4 receptor

The cobalt/bicarbonate solution is a sensitive reagent for hydrogen peroxide, which facilitates the assessment of catalase enzyme at low concentrations of substrate, confirming that the auto-inactivation of catalase is reduced during the assessment steps

As critical signaling molecules, BAs have been confirmed to perform multiple biological functions, such as controlling energy (Wang S

& Crabtree, G

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