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NNMT is abundantly expressed in liver and adipose tissue and pathological conditions characterized by increased metabolic demand, such as some cancers, fatty liver disease, and diabetes

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ADO leads to tumor growth and skews the immune cells toward an immunosuppressive phenotype ( Figure 2 Adenosinergic pathways identified on different cell populations ( ADO is produced from the catabolism of mono- and di-nucleotides of adenine (ATP, NAD + and cAMP) (Figure 1)